Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5004681

Title:Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Inventors:Boyse, Edward A.; New York, NY, USA
Broxmeyer, Hal E.; Indianapolis, IN, USA
Douglas, Gordon W.; New York, NY, USA
Summary:This invention describes methods and compositions for the isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells. Described herein are hematopoietic stem and progenitor cells of neonatal or fetal blood and methods by which they may be cryopreserved and administered for autologous hematopoietic reconstitution in the treatment of a variety of diseases such as anemia and immune deficiencies. Further disclosed are methods by which fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence may be used for hematopoietic reconstitution in gene therapy.
Abstract:The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of the invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for autologous (self) reconstitution.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5004681
Application Number:US1987000119746
Date Filed:12/11/1987
Date Published:02/04/1991
Assignee:Biocyte Corporation, New York, NY, USA


 
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