Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5032507

Title:Potentiation of erythropoiesis
Inventors:Yu, John; San Diego, CA, USA
Yu, Alice L.; San Diego, CA, USA
Vaughan, Joan; San Diego, CA, USA
Rivier, Jean E. F.; La Jolla, CA, USA
Vale, Jr., Wylie W.; La Jolla, CA, USA
Summary:Described herein is a method of modulating erythropoiesis using a follicle-stimulating hormone-releasing protein. The invention relates to a method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells via the use of FRP which has been shown to be an efficacious potentiator of erythropoietin-induced differentiation. Also provided are properties of inhibin which has been shown to be an efficacious suppressor of erythropoietin-induced differentiation. Further disclosed are methods by which FRP and inhibin are shown to be functional antagonists of each other and may therefore be used in combination as an effective means for the modulation of erythropoiesis. Therapeutic applications are included for various diseases which are caused by or associated with an abnormal rate of erythropoiesis.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5032507
Application Number:US1987000120470
Date Filed:13/11/1987
Date Published:16/07/1991
Assignee:The Salk Institute for Biological Studies, San Diego, CA, USA The Regents of the University of California, Berkeley, CA, USA Scripps Clinic and Research Foundation, La Jolla, CA, USA


 
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