Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5035994

Title:Human stem cells and monoclonal antibodies
Inventors:Civin, Curt I.; Baltimore, MD, USA
Summary:Described herein are methods of isolating pluripotent lympho-hematopoietic stem cells from marrow or a blood suspension using monoclonal antibodies. The invention relates to the use of monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells and methods of their use in isolating cell suspensions from human blood and marrow which in turn may be employed in bone marrow transplantation. Further disclosed are properties of cell suspensions containing human pluripotent lympho-hematopoietic stem cells, and uses thereof. Therapeutic applications are provided in gene therapy, bone marrow transplantation, and in the treatment of leukemia and cancer. This invention represents a continuation of other applications filed by the same assignee and inventor.
Abstract:Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as therapeutic methods employing the cell suspensions.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5035994
Application Number:US1990000580337
Date Filed:07/09/1990
Date Published:30/07/1991
Assignee:The Johns Hopkins University, Baltimore, MD, USA


 
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