Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5049659

Title:Proteins which induce immunological effector cell activation and chemattraction
Inventors:Cantor, Harvey I.; Wellesley, MA, USA
Patarca, Roberto M.; Brookline, MA, USA
Schwartz, Joel L.; Newton Centre, MA, USA
Summary:This invention introduces a recombinant activation protein which is expressed by lymphoid cells and which induces immunological effector cell activation and chemattraction. Described herein are genes and their encoded proteins which induce immunological effector cell activation and chemattraction according to the ability of the proteins to attract subsets of immunological effector cells and to stimulate these cells to express their specialized effector cell functions. Further disclosed are properties of such proteins, termed Ap-1 proteins, which are expressed by lymphoid cells and which bind to effector cells such as macrophages and mast cells, such that the Ap-1 proteins induce macrophage phagocytosis, the expression of class II major histocompatibility molecules, cytotoxicity, migration, and the differentiation of hematopoietic progenitor cells. Therapeutic applications of the Ap-1 molecules are included for the diagnosis and treatment of inflammatory or immune disorders such as neoplasia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5049659
Application Number:US1988000153887
Date Filed:09/02/1988
Date Published:17/09/1991
Assignee:Dana Farber Cancer Institute, Boston, MA, USA


 
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