Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5112607

Title:Potentiation of immunotoxin action by Brefeldin A
Inventors:Hudson, Thomas H.; Bethesda, MD, USA
King, Michael A.; Laurel, MD, USA
Summary:Described herein is a process for potentiating immunotoxin action via the use of small, non-toxic concentrations of Brefeldin A. The invention provides methods and materials for the use of Brefeldin A as an immunopotentiator in an immunotoxin or target-cell stem wherein the Brefeldin A has been shown to enhance the immunotoxin pathway while blocking or inhibiting the nonspecific pathway. Further disclosed are methods by which Brefeldin A has been shown to potentiate the cytotoxicity of toxic A chains containing conjugates. Therapeutic applications are included for the in vivo and in vitro use of Brefeldin A in conjunction with immunotoxins made from holotoxins.
Abstract:A method of potentiating immunotoxin action in an immunotoxin/target-cell stem in which Brefeldin A is utilized as an immunopotentiator. The Brefeldin A enhances the immunotoxin pathway while blocking or inhibiting the nonspecific pathway, thus being particularly useful in conjunction with immunotoxins made from holotoxins. The Brefeldin A is effective in small, nontoxic concentrations and therefore may be utilized with either in vivo or in vitro systems.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5112607
Application Number:US1991000715094
Date Filed:05/06/1991
Date Published:12/05/1992
Assignee:The USA as represented by the Secretary of the Army, Washington, DC, USA


 
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