Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5132212

Title:SCL gene, and a hematopoietic growth and differentiation factor encoded thereby
Inventors:Kirsch, Ilan R.; Potomac, MD, USA
Begley, C. Glenn; Victoria, Australia
Summary:This invention describes the human stem cell leukemia (SCL) gene and the hematopoietic growth and differentiation factor encoded by it. Disclosed herein is a new gene which has been identified as being involved in a chromosomal translocation that is associated with the occurrence of a SCL manifesting myeloid and lymphoid differentiation capabilities. Further provided are sequences of a cDNA for the normal SCL transcript and for an aberrant fusion transcript that is produced in the leukemic cells such that the pattern of expression of SCL mRNA is predominant in early hematopoietic tissue, implicating SCL in the differentiation and commitment of events during hematopoiesis.
Abstract:We have identified a new human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Lyl-1, myc, MyoD, Ig enhancer binding, daughterless, and achaete-scute families of genes. For these cDNAs, two forms of the SCL protein (greater than 20 and 30 kD) are predicted, both of which retain this putative DNA binding domain. The pattern of expression of SCL mRNA is primarily predominant in early hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5132212
Application Number:US1989000437819
Date Filed:17/11/1989
Date Published:21/07/1992
Assignee:The USA as represented by the Secretary of the Department of Health and Human Services, Washington, DC. USA


 
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