Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5147784

Title:T-lymphocyte progenitor cell assay
Inventors:Peault, Bruno; Menlo Park, CA, USA
Summary:This invention introduces an assay for human T-lymphocyte progenitor cells. Described herein is a method of using test cells to repopulate lymphoid-depleted thymus tissue which may then be implantation into mice for the detection of donor lymphocytes. Specifically disclosed are processes by which human thymus tissue is depleted of endogenous lymphold cells, repopulated with the human cellular composition HLA, mismatched with the thymus tissue and implanted into a vascularizable site in an immunocompromised host. Also provided are methods by which the tissue may be assayed after a time period of approximately 2 weeks for the presence of the HLA mismatched T-lymphocytes which are indicative of human T-lymphocyte progenitors in the cellular composition.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5147784
Application Number:US1990000508225
Date Filed:12/04/1990
Date Published:15/09/1992
Assignee:SyStemix, Inc., Palo Alto, CA, USA


 
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