Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5175384

Title:Transgenic mice depleted in mature T-cells and methods for making transgenic mice
Inventors:Krimpenfort, Paulus J. A.; Amsterdam, Netherlands Berns, Antonius J. M.; Spaarndam, Netherlands
Summary:Described herein are transgenic nonhuman mammals depleted of mature lymphocytic cells, methods and uses thereof. The invention relates to transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in the mice, such that the phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. Further disclosed are properties of the transgene such that it comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte, namely the ?V-TCR? DNA fragment which encodes a T-cell antigen receptor polypeptide variant which is incapable of mediating T-cell maturation in the transgenic mouse.
Abstract:Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5175384
Application Number:US1988000280218
Date Filed:05/12/1998
Date Published:29/12/1992
Assignee:GenPharm International, Mountain View, CA, USA


 
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