|
|
|
Stem Cell Related Patent Number US5175384
| Title: | Transgenic mice depleted in mature T-cells and methods for making transgenic mice | | Inventors: | Krimpenfort, Paulus J. A.; Amsterdam, Netherlands
Berns, Antonius J. M.; Spaarndam, Netherlands | | Summary: | Described herein are transgenic nonhuman mammals depleted of mature lymphocytic cells, methods and uses thereof. The invention relates to transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in the mice, such that the phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. Further disclosed are properties of the transgene such that it comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte, namely the ?V-TCR? DNA fragment which encodes a T-cell antigen receptor polypeptide variant which is incapable of mediating T-cell maturation in the transgenic mouse. | | Abstract: | Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5175384 | | Application Number: | US1988000280218 | | Date Filed: | 05/12/1998 | | Date Published: | 29/12/1992 | | Assignee: | GenPharm International, Mountain View, CA, USA |
|
|
