Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5185438

Title:Nucleic acids encoding hencatoporetic stem cell receptor flk-2
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein are methods for stimulating the proliferation and differentiation of primitive mammalian hematopoietic stem cells using a ligand that binds to thymidine kinase and flk-1 and flk-2. The invention relates to isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells but not in mature hematopoietic cells. Further disclosed are properties of associated ligands for the receptors, the nucleic acide sequences that encode the ligands, the receptors encoded by such nucleic acid molecules, and the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences of flk-2 and flk-1. This invention represents a continuation of other applications filed by the same assignee and inventor.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1 (flk-2) and FIG. 2 (flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1 (flk-2) and FIG. 2 (flk-1); ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5185438
Application Number:US1991000813593
Date Filed:24/12/1991
Date Published:09/02/1993
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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