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Stem Cell Related Patent Number US5192553

Title:Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
Inventors:Boyse, Edward A.; Tucson, AZ, USA
Broxmeyer, Hal E.; Indianapolis, IN, USA
Douglas, Gordon W.; New York, NY, USA
Summary:This invention describes a method for obtaining human neonatal and hematopoietic stem or progenitor cells, and uses thereof. Described herein are methods by which hematopoietic stem and progenitor cells of neonatal or fetal blood are isolated, cryopreserved and thawed for use in hematopoietic or immune reconstitution. Therapeutic applications are included in gene therapy and for the use of such cells in the treatment of various diseases and disorders such as anemias, malignancies, autoimmune disorders and various immune dysfunctions and deficiencies.
Abstract:The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of he invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for utologous (self) reconstitution.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5192553
Application Number:US1988000269926
Date Filed:10/11/1988
Date Published:09/03/1993
Assignee:Biocyte Corporation, New York, NY, USA


 
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