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Stem Cell Related Patent Number US5214133

Title:SCL: a hematopoietic growth and differentiation factor
Inventors:Kirsch, Ilan R.; Potomac, MD, USA
Begley, C. Glenn; North Carlton, Australia
Summary:This invention introduces a novel human stem cell leukemia (SCL) gene and the hematopoietic growth and differentiation factors encoded by it. The inventors describe their discovery of this new gene through its involvement in a chromosomal translocation that is associated with the occurrence of a SCL that manifests myeloid and lymphoid differentiation capabilities. Disclosed herein is the sequence of a cDNA for the normal SCL transcript as well as for an aberrant fusion transcript produced in the leukemic cells, and mechanisms by which the properties of SCL are involved in the differentiation and commitment of cells during hematopoiesis.
Abstract:We have identified a new human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid and lymphoid differentiation capabilities. Here we report the sequence of a cDNA for the normal SCL transcript, as well as for an aberrant fusion transcript produced in the leukemic cells. Although different at their 3' untranslated regions, both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix-loop-helix DNA binding and dimerization motif of the Lyl-1, myc, MyoD, Ig enhancer binding, daughterless, and achaete-scute families of genes. For these cDNAs, two forms of the SCL protein (greater than 20 and 30 kD) are predicted, both of which retain this putative DNA binding domain. The pattern of expression of SCL mRNA is primarily predominant in early hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5214133
Application Number:US1992000826470
Date Filed:27/01/1992
Date Published:25/05/1993
Assignee:The USA as represented by the Secretary of the Department of Health and Human Services, Washington, DC, USA


 
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