Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5250732

Title:Ketamine analogues for treatment of thrombocytopenia
Inventors:Kogan, Timothy P.; Half Moon Bay, CA, USA
Somers, Todd C.; Montara, CA, USA
Summary:Described herein are dehydronorketamine derivatives and methods of their use in the treatment of thrombocytopenia. The invention relates to 5,6-Dehydronorketamine and derivatives retaining the ?a,?-unsaturated carbonyl which are shown to influence the replication, differentiation or maturation of blood cells such as platelet progenitor cells in a manner similar to that of Michael or Michael-type acceptors and adducts. Therapeutic applications of such compounds are directed toward the treatment of thrombocytopenia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5250732
Application Number:US1991000732365
Date Filed:18/07/1991
Date Published:05/10/1993
Assignee:Genentech, Inc., South San Francisco, CA, USA


 
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