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Stem Cell Related Patent Number US5270458

Title:Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein are isolated nucleic acid molecules of the hematopoietic stem cell receptor flk-2 and its fragments. The invention relates to isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases which are expressed in primitive hematopoietic cells but not in mature hematopoietic cells. Further disclosed are associated ligands, nucleic acid sequences encoding the ligands, receptors encoded by such nucleic acid molecules, and the nucleic acid molecules encoding receptor protein tyrosine kinases such as murine flk-2, human flk-2, murine flk-1. This invention represents a continuation of other applications filed by the same assignee and inventor.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5270458
Application Number:US1992000977451
Date Filed:19/11/1992
Date Published:14/12/1993
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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