Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5279969

Title:Method of identifying and modulating the activity of label retaining cells in hair follicles for diagnostic and therapeutic purposes
Inventors:Lavker, Robert M.; Malvern, PA, USA
Sun, Tung-Tien; Scarsdale, NY, USA
Cotsarelis, George; Upper Darby, PA, USA
Summary:Described herein are methods of evaluating the efficacy of agents for the modulation of bulge cell populations. The invention relates to a process of identifying and modulating the activity of label-retaining stem cells which are found in self-renewing tissue such as hair follicles. Further disclosed are methods of modulating the activity of slow-cycling cells and evaluating the efficacy of agents for modulating the activity of stem cell populations. Also provided are techniques by which continuously-labeled cells may be induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria. Therapeutic applications are provided for the diagnosis and treatment of abnormal hair growth and skin cancers. This invention represents a continuation of other applications filed by the same assignees.
Abstract:Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5279969
Application Number:US1992000971687
Date Filed:04/11/1992
Date Published:18/01/1994
Assignee:Trustees of the University of Pennsylvania, Philadelphia, PA, USA New York Univ., New York, NY, USA


 
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