Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5283354

Title:Nucleic acids encoding hematopoietic stem cells receptors flk-1
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein are methods of stimulating the proliferation and differentiation of primitive mammalian hematopoietic stem cells using ligands that bind thymidine kinase and flk-1 and flk-2. The invention relates to isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases as expressed in primitive hematopoietic cells but not in mature hematopoietic cells. Further disclosed are associated ligands for the receptors, nucleic acid sequences that encode the ligands, the receptors encoded by such nucleic acid molecules, and the nucleic acid molecules encoding the receptor protein tyrosine kinases such as flk-2 and flk-1. This invention represents a continuation of other applications filed by the same assignee and inventor.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1(flk-2) and FIG. 2 (flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1(flk-2) and FIG. 2 (flk-1); ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5283354
Application Number:US1992000946507
Date Filed:17/09/1992
Date Published:01/02/1994
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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