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Stem Cell Related Patent Number US5300422
| Title: | Screening method for controlling agranulocytosis | | Inventors: | Gerson, Stanton L.; Pepper Pike, OH, USA
Meltzer, Herbert; Shaker Heights, OH, USA | | Summary: | Described herein is a method of predicting or detecting agranulocytosis during clozapine therapy. The invention relates to a process by which elevated levels of N-desmethylclozapine may be detected in the blood serum or bone marrow of patients, thereby providing a screening method for measuring the vulnerability of patients on clozapine therapy and their risk of developing agranulocytosis. Further disclosed are methods by which the concentration of N-desmethylclozapine may be established in the blood or bone marrow of the patient and their sensitivity to the drug measured by a process of collecting and assaying heparinized blood for stem cell sensitivity to N-desmethylclozapine. | | Abstract: | A screening method for detecting the vulnerability of patients on clozapine therapy to developing agranulocytosis which comprises establishing the concentration of N-desmethylclozapine in the blood or bone marrow of said patient. In addition, a method of determining patient sensitivity to N-desmethylclozapine is provided which comprises collecting heparinized blood and assaying it for stem cell sensitivity to N-desmethylclozapine. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5300422 | | Application Number: | US1991000802162 | | Date Filed: | 04/12/1991 | | Date Published: | 05/04/1994 | | Assignee: | Case Western Reserve University, Cleveland, OH, USA |
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