Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5300422

Title:Screening method for controlling agranulocytosis
Inventors:Gerson, Stanton L.; Pepper Pike, OH, USA
Meltzer, Herbert; Shaker Heights, OH, USA
Summary:Described herein is a method of predicting or detecting agranulocytosis during clozapine therapy. The invention relates to a process by which elevated levels of N-desmethylclozapine may be detected in the blood serum or bone marrow of patients, thereby providing a screening method for measuring the vulnerability of patients on clozapine therapy and their risk of developing agranulocytosis. Further disclosed are methods by which the concentration of N-desmethylclozapine may be established in the blood or bone marrow of the patient and their sensitivity to the drug measured by a process of collecting and assaying heparinized blood for stem cell sensitivity to N-desmethylclozapine.
Abstract:A screening method for detecting the vulnerability of patients on clozapine therapy to developing agranulocytosis which comprises establishing the concentration of N-desmethylclozapine in the blood or bone marrow of said patient. In addition, a method of determining patient sensitivity to N-desmethylclozapine is provided which comprises collecting heparinized blood and assaying it for stem cell sensitivity to N-desmethylclozapine.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5300422
Application Number:US1991000802162
Date Filed:04/12/1991
Date Published:05/04/1994
Assignee:Case Western Reserve University, Cleveland, OH, USA


 
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