Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5358711

Title:Stimulation of stem cell growth by the bryostatins
Inventors:May, W. Stratford; Baltimore, MD, USA
Sensenbrenner, Lyle L.; Grosse Pointe Park, MI, USA
Summary:Described herein are properties of the bryostatins and methods of their use. The invention relates to in vivo and in vitro procedures by which bryostatins may be used for stimulating the differentiation of stem cells, for inducing the formulation of granulocytes, macrophages and erythrocytes, and for activating the cytotoxicity of mature neutrophils. Further disclosed are properties of the acylated C20 carbon which characterizes the bryostatins, and its role in promoting the differentiation of neutrophils and other immune cells. Therapeutic applications are included for the substitution of bryostatins in place of human colony stimulating factors.
Abstract:In vivo and in vitro methods are taught for stimulating the differentiation of stem cells using certain bryostatins. Stem cells can be induced to form granulocytes, macrophages and erythrocytes. In addition, the cytotoxicity of mature neutrophils can be activated. These methods may substitute for those requiring human colony stimulating factors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5358711
Application Number:US1993000118694
Date Filed:10/09/1993
Date Published:25/10/1994
Assignee:Johns Hopkins University, Baltimore, MD, USA


 
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