Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5367057

Title:Tyrosine kinase receptor flk-2 and fragments thereof
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein is a murine flk-2 receptor protein tyrosine kinase and its fragments. The invention relates to isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases that are expressed in primitive hematopoietic cells but not in mature hematopoietic cells. Further disclosed are properties of the receptors encoded by such nucleic acid molecules, associated ligands for the receptors and the nucleic acid molecules themselves which encode the receptor protein tyrosine kinases such as murine flk-2, human flk-2, and murine flk-1. Also provided are methods for stimulating the proliferation and differentiation of primitive mammalian hematopoietic stem cells via contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase as expressed in primitive mammalian hematopoietic cells but not in mature hematopoietic cells. Therapeutic applications are included for the treatment of a variety of diseases. This invention represents a continuation of other applications filed by the same assignee and inventor.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1 (murine flk-2), FIG. 2 (human flk-2) and FIG. 3 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1 (murine flk-2); FIG. 2 (human flk-2) and FIG. 3; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5367057
Application Number:US1993000055269
Date Filed:30/04/1993
Date Published:22/11/1994
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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