Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5384331

Title:Ketamine analogues for treatment of thrombocytopenia
Inventors:Kogan, Timothy P.; Half Moon Bay, CA, USA
Somers, Todd C.; Montara, CA, USA
Summary:Described herein are methods of treating thrombocytopenia by the administration of cyclohexene derivatives. The invention relates to 5,6-Dehydronorketamine and derivatives which retain the ?a,?-unsaturated carbonyl and which are shown to influence the replication, differentiation and maturation of blood cells such as platelet progenitor cells in a manner similar to that of Michael or Michael-type acceptors and adducts. Therapeutic applications of such compounds are directed toward the treatment of thrombocytopenia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5384331
Application Number:US1993000069245
Date Filed:28/05/1993
Date Published:24/01/1995
Assignee:Genentech, Inc., South San Francisco, CA, USA


 
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