Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5472867

Title:Ex vivo expansion of peripheral blood progenitor
Inventors:Kanz, Lothar; Freiburg, Germany
Brugger, Woefram; Kirchzarten, Germany
Mestepsmann, Roland; Freiburg, Germany
Summary:Described herein are methods and compositions for the ex vivo expansion of hematopoietic precursor cells via the use of interleukins 1,3 and 6, erythropoietin and stem cell growth factor. The invention addresses the problem of recovery after the administration of high-dose chemotherapy to cancer patients. Disclosed herein is a process for the ex vivo expansion of peripheral blood progenitor cells wherein CD 34+ cells are enriched and cultivated in a medium comprising IL-1, IL-3, IL-6, EPO and SCF. Claims of the invention include the generation of cells of high clonogenic potential which have the capacity to expedite recovery from chemotherapy in cancer patients. This invention represents a continuation of other applications filed by the same assignee and inventors.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5472867
Application Number:US1993000128884
Date Filed:29/09/1993
Date Published:05/12/1995
Assignee:Klinikum Der Albert-Ludwigs-Universitat Freiberg, Freiberg, Germany


 
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