Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5523226

Title:Transgenic swine compositions and methods
Inventors:Wheeler, Matthew B.; Tolono, IL, USA
Summary:Described herein are chimeric and transgenic ungulates, methods and uses thereof. The invention relates to transgenic swine generated from porcine (Sus scrofa) embryonic stem cell lines which are transformed with exogenous genetic material of interest and used to produce the chimeric swine which have germ cells comprising the exogenous genetic material, and which are then bred to produce the transgenic swine. Therapeutic applications are included for the use of such transgenic swine as a source of human proteins or peptide hormones and for use as xenograft donors.
Abstract:Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5523226
Application Number:US1993000063095
Date Filed:14/05/1993
Date Published:04/06/1996
Assignee:Biotechnology Research and Development Corp., Peoria, IL, USA Board of Trustees of the University of Illinois, Urbana, IL, USA


 
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