Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5554512

Title:Ligands for flt3 receptors
Inventors:Lyman, Stewart D.; Seattle, WA, USA
Beckmann, M. Patricia; Poulsbo, WA, USA
Summary:This invention describes isolated ligands for flt 3 receptors, methods and uses thereof. Disclosed herein are ligands for flt3 receptors which are capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells. Further described are properties of flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammalian host using flt3-L, and methods of improving transplantations using flt3-L. Therapeutic applications are included for the treatment of anaemia, AIDS and various cancers.
Abstract:Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5554512
Application Number:US1994000243545
Date Filed:11/05/1994
Date Published:10/09/1996
Assignee:Immunex Corporation


 
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