Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5556942

Title:Glutathione S-transferase-activated compounds
Inventors:Kauvar, Lawrence M.; San Francisco, CA, USA
Lyttle, Matthew H.; Point Reyes Station, CA, USA
Satyam, Apparao; Fremont, CA, USA
Summary:Described herein are novel compounds and methods of their use for treating MCF-7 cells. The invention relates to novel compositions and the amides, esters or salts thereof, such that the compositions are prodrugs which may be utilized for the selective treatment of target tissues containing compatible glutathione S-transferase (GST) isoenzymes. Claims of the invention include an elevation in the levels of GM progenitor cells in bone marrow upon contact with these compositions. Specific chemical configurations are elucidated. Therapeutic applications are provided for the use of these peptide derivatives which are prodrugs for cytotoxic drugs.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5556942
Application Number:US1994000309005
Date Filed:19/09/1994
Date Published:17/09/1996
Assignee:Terrapin Technologies, Inc., South San Francisco, CA, USA


 
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