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Stem Cell Related Patent Number US5556942
| Title: | Glutathione S-transferase-activated compounds | | Inventors: | Kauvar, Lawrence M.; San Francisco, CA, USA
Lyttle, Matthew H.; Point Reyes Station, CA, USA
Satyam, Apparao; Fremont, CA, USA | | Summary: | Described herein are novel compounds and methods of their use for treating MCF-7 cells. The invention relates to novel compositions and the amides, esters or salts thereof, such that the compositions are prodrugs which may be utilized for the selective treatment of target tissues containing compatible glutathione S-transferase (GST) isoenzymes. Claims of the invention include an elevation in the levels of GM progenitor cells in bone marrow upon contact with these compositions. Specific chemical configurations are elucidated. Therapeutic applications are provided for the use of these peptide derivatives which are prodrugs for cytotoxic drugs. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5556942 | | Application Number: | US1994000309005 | | Date Filed: | 19/09/1994 | | Date Published: | 17/09/1996 | | Assignee: | Terrapin Technologies, Inc., South San Francisco, CA, USA |
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