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Stem Cell Related Patent Number US5556954
| Title: | Hematopoietic stem cell specific gene expression | | Inventors: | Burn, Timothy C.; Bedford, MA, USA
Satterthwaite, Anne B.; Brighton, MA, USA
Tenen, Daniel G.; Boston, MA, USA | | Summary: | Described herein is a novel promoter and enhancer from the CD34 gene, methods and uses thereof. The invention relates to a hematopoietic stem cell-specific promoter, to its associated enhancer and to a specific promoter-heterologous gene construct wherein the expression of the heterologous gene is under the control of the myeloid cell type specific promoter. Further disclosed are methods for the production of a transgenic non-human mammal in which the hematopoietic stem cells express a protein encoded by a heterologous gene. Therapeutic applications are included by which factors regulating hematopoietic stem cell-specific transcription may be expressed for the treatment of a variety of diseases. | | Abstract: | The subject application relates to a hematopoietic stem cell specific promoter and to a hematopoietic stem cell specific enhancer and to uses therefor. The invention also includes a hematopoietic stem cell specific promoter-heterologous gene construct, where the expression of the heterologous gene is under the control of the myeloid cell type specific promoter. Additionally, the application is drawn to a method of expressing a heterologous gene in a hematopoietic stem cell. The invention further includes a method of expressing a selected heterologous gene product in hematopoietic stem cells in an individual. The invention also includes a transgenic non-human mammal in which the hematopoietic stem cells express a protein encoded by a heterologous gene. Finally the invention includes a method for identifying factors which can regulate hematopoietic stem cell specific transcription. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5556954 | | Application Number: | US1992000990965 | | Date Filed: | 15/12/1992 | | Date Published: | 17/09/1996 | | Assignee: | Beth Israel Hospital Association, Boston, MA, USA |
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