Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5556954

Title:Hematopoietic stem cell specific gene expression
Inventors:Burn, Timothy C.; Bedford, MA, USA
Satterthwaite, Anne B.; Brighton, MA, USA
Tenen, Daniel G.; Boston, MA, USA
Summary:Described herein is a novel promoter and enhancer from the CD34 gene, methods and uses thereof. The invention relates to a hematopoietic stem cell-specific promoter, to its associated enhancer and to a specific promoter-heterologous gene construct wherein the expression of the heterologous gene is under the control of the myeloid cell type specific promoter. Further disclosed are methods for the production of a transgenic non-human mammal in which the hematopoietic stem cells express a protein encoded by a heterologous gene. Therapeutic applications are included by which factors regulating hematopoietic stem cell-specific transcription may be expressed for the treatment of a variety of diseases.
Abstract:The subject application relates to a hematopoietic stem cell specific promoter and to a hematopoietic stem cell specific enhancer and to uses therefor. The invention also includes a hematopoietic stem cell specific promoter-heterologous gene construct, where the expression of the heterologous gene is under the control of the myeloid cell type specific promoter. Additionally, the application is drawn to a method of expressing a heterologous gene in a hematopoietic stem cell. The invention further includes a method of expressing a selected heterologous gene product in hematopoietic stem cells in an individual. The invention also includes a transgenic non-human mammal in which the hematopoietic stem cells express a protein encoded by a heterologous gene. Finally the invention includes a method for identifying factors which can regulate hematopoietic stem cell specific transcription.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5556954
Application Number:US1992000990965
Date Filed:15/12/1992
Date Published:17/09/1996
Assignee:Beth Israel Hospital Association, Boston, MA, USA


 
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