Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5571686

Title:Method of using megapoietin for prolonging the survival & viability of platlets
Inventors:Rosenberg, Robert D.; Jamestown, RI, USA
Kuter, David J.; Reading, MA, USA
Beeler, David; Cambridge, MA, USA
Summary:This invention introduces novel thrombopoietin and megapoietin proteins, and methods of their use in the stimulation of platelet production. Described herein are new therapies for treating blood platelet disorders based on the megapoietin gene and protein which involve use of megapoietin for increasing the storage life of platelets and whole blood preparations, and as a means for selectively targeting therapeutic or imaging agents to arterial clots. Further disclosed are methods by which the proteins may be utilized as a means for selectively stimulating platelet production from megakaryocytes in vivo and in vitro. Therapeutic applications are included for preventing and treating blood platelet disorders, increasing the storage life of blood, and for stimulating cell growth.
Abstract:New therapies for treating blood platelet disorders based on the megapoietin gene and protein are described. Additional utilities for megapoietin such as increasing the storage life of platelet and whole blood preparations, a means for selectively targeting therapeutic or imaging agents to arterial clots, and a means for selectively stimulating platelet production from megakaryocytes in vivo and in vitro (e.g., as a source of platelets for transplantation) and to stimulate stem cell growth are also described.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5571686
Application Number:US1994000227530
Date Filed:14/04/1994
Date Published:05/11/1996
Assignee:Massachusetts Institute of Technology, Cambridge, MA, USA


 
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