Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5591625

Title:Transduced mesenchymal stem cells
Inventors:Gerson, Stanton L.; Pepper Pike, OH, USA
Caplan, Arnold I.; Cleveland Heights, OH, USA
Haynesworth, Stephen E.; Cleveland Heights, OH, USA
Summary:Described herein are genetically transformed human stem cells that have been transfected with exogenous genetic material. The invention relates to genetically engineered and isolated human mesenchymal stem cells that carry within them genes of interest encoding for the expression of physiologically or pharmacologically active proteins which can differentiate into more than one connective tissue type, such that the tissue is transfected with the exogenous genetic material encoding the protein to be expressed. Claims of the invention include the ability to introduce, in a targeted manner, additional copies of essential genes into cells in order to allow the expression in proliferating, nondifferentiating cells of these specific gene products which can then be utilized in hormone matrix proteins, cytokines, adhesion molecules and detoxification enzymes. Therapeutic applications are included for tissue repair and for the correction of genetic disorders by gene therapy.
Abstract:Genetically engineered human stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins or for use in gene therapy. In addition to correction of genetic disorders, is the ability to introduce, in a targeted manner, additional copies of essential genes to allow expression in proliferating, nondifferentiating cells of certain gene products. These genes can be, for example, hormones matrix proteins, cytokines, adhesion molecules, detoxification enzymes and rebuilding proteins important in tissue repair.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5591625
Application Number:US1993000158000
Date Filed:24/11/1993
Date Published:07/01/1997
Assignee:Case Western Reserve University, Cleveland, OH, USA


 
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