Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5593863

Title:Administration of an RNA stem loop structure to modulate protein synthesis
Inventors:Eberwine, James H.; Philadelphia, PA, USA
Spencer, Corinne; Philadelphia, PA, USA
Summary:Described herein is a method of modulating the synthesis of pro-opiomelanocortin in mammals via the administration of a molecule which is capable of binding to a specific region of the pro-opiomelanocortin. The invention relates to a process by which synthesis of this protein is modulated in a cell or tissue by contacting the cell or tissue with at least a portion of the mRNA stem-loop structure of the pro-opiomelanocortin, which thereby modulates the synthesis. Claims of the invention include increased synthesis of the protein according to this method. Further described are compositions containing the mRNA stem-loop structure and properties thereof.
Abstract:A method for modulating synthesis of a selected protein in a cell or tissue by contacting the cell or tissue with at least a portion of a mRNA stem loop structure are provided. Compositions containing a mRNA stem loop structure are also provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5593863
Application Number:US1994000327393
Date Filed:19/10/1994
Date Published:14/01/1997
Assignee:Trustees of the University of Pennsylvania, Philadelphia, PA, USA


 
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