Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5605829

Title:Stroma-derived stem cell proteoglycan growth factor
Inventors:McGlave, Philip B.; St. Paul, MN, USA
Verfaillie, Catherine M.; St. Paul, MN, USA
Gupta, Pankaj; Minneapolis, MN, USA
Summary:This invention describes methods of cultivation of hematopoietic stem cells in media containing new synthetic proteoglycans. Further described is an anionic macromolecule containing a composition that is capable of supporting conservation and differentiation of long-term bone marrow culture-initiating cells in cultured mammalian hematopoietic cells. The composition under consideration is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD. Emphasis is given to a synthetic proteoglycan, having a core protein and a polysaccharide portion, which is capable of promoting differentiation and maintaining the self-renewal capacity of long-term bone marrow culture-initiating cells in cultured mammalian hematopoietic cells. The polysaccharide portion of the synthetic proteoglycan comprises heparin sulfate, chondroitin sulfate, dermatan sulfate or a combination thereof, and the core protein comprises ovalbumin.
Abstract:An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5605829
Application Number:US1994000346893
Date Filed:30/11/1994
Date Published:25/02/1997
Assignee:Regents of the University of Minnesota, Minneapolis, MN, USA


 
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