Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5610056

Title:Use of stem cell factor interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells
Inventors:Nakahata, Tatsutoshi; Tokyo, Japan
Summary:Described herein are methods for the ex vivo expansion of multipotent hematopoietic cells via a process of culturing the cells with a combination of cytokines such as interleukin-6 and soluble interleukin-6 receptor in the presence of stem cell factor. Claims of the invention include improved proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells in a culture medium comprised with this combination of cytokines and stem cell factor. Therapeutic applications are included.
Abstract:Stem cell factor in combination with interleukin-6 and soluble interleukin-6 receptor supports proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5610056
Application Number:US1994000340559
Date Filed:16/11/1994
Date Published:11/03/1997
Assignee:Amgen Inc., Thousand Oaks, CA, USA Tosoh Corporation, Tokyo, Japan


 
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