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Stem Cell Related Patent Number US5614184
| Title: | Recombinant human erythropoietin mutants and therapeutic methods employing them | | Inventors: | Sytkowski, Arthur J.; Arlington, MA, USA
Grodberg, Jennifer; Montreal, Canada | | Summary: | Disclosed herein are mutant human erythropoietin proteins, methods and uses thereof. The invention relates to DNA encoding modified, secretable erythropoietin proteins with the capacity to regulate the growth and differentiation of red blood cell progenitors. Such proteins are described as differing from wildtype recombinant erythropoietin at the position corresponding to glycine101 of the wildtype erythropoietin, such that the mutant protein has an increased biological activity as determined by an in vitro erythropoietic bioassay. Further disclosed are methods of modifying or altering the regulating activity of a secretable erythropoietin, and applications for the use of such modified secretable erythropoietin proteins. Therapeutic uses are included for both the promotion and the inhibition of red blood cell progenitor growth and differentiation in the treatment of a variety of diseases. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5614184 | | Application Number: | US1995000383743 | | Date Filed: | 02/02/1995 | | Date Published: | 25/03/1997 | | Assignee: | New England Deaconess Hospital, Boston, MA, USA |
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