Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5614187

Title:Specific tolerance in transplantation
Inventors:Sachs, David H.; Newton, MA, USA
Summary:This invention introduces a nucleic acid encoding the mammalian MHC antigen and its uses in transplantation. The invention relates to a method of inducing tolerance in a recipient mammal of one species, such as a human, to a tissue obtained from a mammal of a different species, such as a swine or a miniature swine, from which tissue is obtained which expresses the MHC antigen. Further disclosed are methods of inserting ex vivo the DNA encoding the MHC antigen of the second species into a bone marrow hematopoietic stem cell from the recipient mammal, and allowing the MHC antigen encoding the DNA to be expressed in the recipient. Therapeutic applications are directed specifically toward the prevention of tissue rejection in transplantation.
Abstract:In general, the invention features, a method of inducing tolerance in a recipient mammal, e.g., a human, of a first species to a tissue obtained from a mammal, e.g., a swine, e.g., a miniature swine, of a second species, which tissue expresses an MHC antigen, including inserting DNA encoding an MHC antigen of the second species into a bone marrow hematopoietic stem cell from the recipient mammal, and allowing the MHC antigen encoding DNA to be expressed in the recipient.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5614187
Application Number:US1994000266427
Date Filed:27/06/1994
Date Published:25/03/1997
Assignee:The General Hospital Corporation, Boston, MA, USA The USA as represented by the Department of Health and Human Services, Washington, DC, USA


 
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