Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5614396

Title:Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
Inventors:Bradley, Allan; Houston, TX
Davis, Ann; Houston, TX
Hasty, Paul; Houston, TX
Summary:This invention describes a method for producing animal cells in chimeric or transgenic non-human animals which contain a desired gene sequence inserted into a predetermined gene sequence. The method permits the production of animal cells and non-human animals which have subtle and precise modifications of gene sequence and expression relative to natural non-human animals. After the DNA molecule with the specific, desired sequence is introduced into the mammalian cell, the introduced DNA molecule is then allowed to undergo homologous recombination with the predetermined gene sequence of the mammalian cell, thereby producing an intermediate cell; culturing of the intermediate cells, and the consequent intrachromosomal recombination are also disclosed.
Abstract:A method for producing animal cells, chimeric or transgenic non-human animals which contain a desired gene sequence inserted into a predetermined gene sequence. The method permits the production of animal cells and non-human animals which have subtle and precise modifications of gene sequence and expression relative to natural non-human animals.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5614396
Application Number:US1994000200011
Date Filed:22/02/1994
Date Published:25/03/1997
Assignee:Baylor College of Medicine, Houston, TX, USA


 
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