Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5625126

Title:Transgenic non-human animals for producing heterologous antibodies
Inventors:Lonberg, Nils; Redwood City, CA
Kay, Robert M.; San Francisco, CA
Summary:This invention consists of a transgenic mouse which contains in its genome a transgene comprising in operable linkage a plurality of various human genes and associated isotype switching sequences, specific groups of which are located in closer proximity to each other than in the naturally occurring human immunoglobulin locus. The transgenic mouse also contains lymphocytes which undergo productive VDJ rearrangement by recombination between certain switch sequences. The mouse thereby produces a serum containing immunoglobulins of a minimum of 3 human heavy chain isotypes in response to antigenic stimulation.
Abstract:The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5625126
Application Number:US1994000352322
Date Filed:07/12/1994
Date Published:29/04/1997
Assignee:GenPharm International, Inc., Palo Alto, CA, USA


 
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