Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US5635388

Title:Agonist antibodies against the flk2/flt3 receptor and uses thereof
Inventors:Bennett, Brian D.; Pacifica, CA, USA
Broz, SUSA
n D.; San Bruno, CA, USA
Matthews, William; Woodside, CA, USA
Zeigler, Francis C.; San Mateo, CA, USA
Summary:This invention describes agonist antibodies which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells, and the antibodies are able to cause primitive hematopoietic cells to proliferate and/or to differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, among other disorders.
Abstract:Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5635388
Application Number:US1994000222299
Date Filed:04/04/1994
Date Published:03/06/1997
Assignee:Genentech, Inc., South San Francisco, CA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/23/2021