Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5649904

Title:Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both
Inventors:Gianni, Alessandro M.; Milan, Italy
Summary:Described herein is a protocol for the autologous transplantation of bone marrow. The invention relates to the sequential use of an agent which is cytotoxic to tumors but not to stem cells, followed by the administration of a granulocyte-macrophage colony-stimulating factor. Claims of the invention include high harvesting potential of large numbers of multipotent hemopoietic precursor cells derived in this manner, and a reduction in the period of time required for myeloid recovery after high-dose chemotherapy or radiotherapy. Therapeutic applications are directed toward the treatment of cancer patients with such a myeloablative regime following chemotherapy, radiation therapy or both.
Abstract:The use, in sequence, of a cytotoxic, but stem cell sparing, agent and granulocyte-macrophage colony stimulating factor as a means to harvest very high numbers of multipotential haemopoietic precursor cells and in reducing the period of myeloid recovery after high dose chemo- or radiotherapy of cancer.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5649904
Application Number:US1995000452461
Date Filed:26/05/1995
Date Published:22/07/1997
Assignee:Sandoz Ltd., Basle, Switzerland


 
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