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Stem Cell Related Patent Number US5649904
| Title: | Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both | | Inventors: | Gianni, Alessandro M.; Milan, Italy | | Summary: | Described herein is a protocol for the autologous transplantation of bone marrow. The invention relates to the sequential use of an agent which is cytotoxic to tumors but not to stem cells, followed by the administration of a granulocyte-macrophage colony-stimulating factor. Claims of the invention include high harvesting potential of large numbers of multipotent hemopoietic precursor cells derived in this manner, and a reduction in the period of time required for myeloid recovery after high-dose chemotherapy or radiotherapy. Therapeutic applications are directed toward the treatment of cancer patients with such a myeloablative regime following chemotherapy, radiation therapy or both. | | Abstract: | The use, in sequence, of a cytotoxic, but stem cell sparing, agent and granulocyte-macrophage colony stimulating factor as a means to harvest very high numbers of multipotential haemopoietic precursor cells and in reducing the period of myeloid recovery after high dose chemo- or radiotherapy of cancer. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5649904 | | Application Number: | US1995000452461 | | Date Filed: | 26/05/1995 | | Date Published: | 22/07/1997 | | Assignee: | Sandoz Ltd., Basle, Switzerland |
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