Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5650299

Title:Cells producing stem cell proliferation factor
Inventors:Lawman, Michael J. P.; Orlando, FL, USA
Lawman, Patricia D.; Orlando, FL, USA
Denslow, Nancy D.; Gainesville, FL, USA
Summary:Described herein are cell lines producing a stem cell proliferation factor (SCPF), namely, an autocrine growth factor. The invention relates to a protein which exists in two forms, a soluble form and a membrane bound form which is detectable on the surface of a small percentage of human bone marrow cells and which stimulates the proliferation of these cells. Claims of the invention include a wide range of applications for the use of this SCPF in augmenting hematopoietic stem cell growth. Further disclosed are properties of associated cell lines including molecular weights, membrane fractions, isoelectric points of isoforms and binding activity. Therapeutic applications are included for removal of the protein by an antibody in the control of tumor cell growth.
Abstract:The present invention is directed to an autocrine growth factor. In particular, it relates to the production, purification and uses of stem cell proliferation factor (SCPF). In various cell lines, the protein of the invention exists in two forms, a soluble form and a membrane bound form which is detectable on the surface of a small percentage of human bone marrow cells and stimulates the proliferation of these cells. Therefore, SCPF may have a wide range of applications including but not limited to augmenting the growth of hematopoietic stem cells. Further, removal of the protein by an antibody may be useful in controlling tumor cell growth.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5650299
Application Number:US1994000319165
Date Filed:06/10/1994
Date Published:22/07/1997
Assignee:The University of Florida, Gainesville, FL, USA


 
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