Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5652337

Title:OP-3-induced morphogenesis
Inventors:Oppermann, Hermann; Medway, MA, USA
Ozkaynak, Engin; Milford, MA, USA
Kuberasampath, Thangavel; Medway, MA, USA
Rueger, David C.; Hopkinton, MA, USA
Pang, Roy H. L.; Etna, NH, USA
Cohen, Charles M.; Medway, MA, USA
Summary:Described herein is an isolated morphogenically active dimeric protein, designated MOP-3, methods and uses thereof. The invention relates to nucleic acid and amino acid sequences for MOP-3, and methods by which it may be produced and expressed in a biologically active form. Further disclosed are techniques by which it may be used to induce tissue morphogenesis in a mammal, and to increase a progenitor cell population in a mammal, and to stimulate progenitor cells to differentiate and maintain their differentiated phenotype both in vivo and in vitro. Therapeutic applications are included for the use of this protein in inducing tissue morphogenesis in mammals for the replacement of diseased or damaged tissue in vivo. This invention represents a continuation of other applications filed by the same assignee.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5652337
Application Number:US1995000479666
Date Filed:07/06/1995
Date Published:29/07/1997
Assignee:Creative BioMolecules, Inc., Hopkinton, MA, USA


 
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