Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5665350

Title:Cell cycle dependent transplantation and ex vivo gene therapy
Inventors:Quesenberry, Peter J.; Shrewsburg, MA, USA
Summary:This invention describes a method of introducing cells into a host mammal via the transplantation of quiescent stem cells. Described herein is a stem cell population and related compositions for the enhancement of bone marrow stem cell engraftment. Further disclosed are methods by which the pluripotent cells are expanded and optionally transfected such that quiescence is induced. Claims of the invention include improved long-term engraftment. Therapeutic applications are directed toward transplantation and ex vivo gene therapy, especially in the enhancement of bone marrow stem cell engraftment.
Abstract:Methods for the enhancement of bone marrow stem cell engraftment are provided for use in transplantation therapy and ex vivo gene therapy of a mammal. The methods involve the transplantation of quiescent stem cells for transplantation therapy and quiescent transfected stem cells for ex vivo gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5665350
Application Number:US1994000344080
Date Filed:23/11/1994
Date Published:09/09/1997
Assignee:University of Massachusetts Medical Center, Worcester, MA, USA


 
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