Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5665557

Title:Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof
Inventors:Murray, Lesley; San Jose, CA, USA
Sutherland, D. Robert; Oakville, Canada
Summary:Described herein are methods of obtaining a composition enriched in hematopoietic stem cells. The invention relates to a process by which cells expressing the marker CDw109 are identified and separated. Further disclosed are methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells. Also provided are methods for contacting the population with the monoclonal antibody specific for the marker CDw109, and separating the subpopulation that is specifically bound by the monoclonal antibody. Claims of the invention include a resulting composition which is substantially enriched in a subpopulation of human hematopoietic stem cells. Therapeutic and experimental applications are included.
Abstract:The invention relates to methods of obtaining compositions enriched in hematopoietic stem cells by separating out an enriched fraction of cells expressing the marker CDw109. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention. Methods of use of the cells are also included.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5665557
Application Number:US1994000340048
Date Filed:14/11/1994
Date Published:09/09/1997
Assignee:SyStemix, Inc., Palo Alto, CA, USA The Toronto Hospital Research Institute, Toronto, Canada


 
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