Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5668104

Title:Hematopoietic stem cell growth-promoting compositions containing a fibroblast-derived fragment of fibronectin and a growth factor, and methods employing them in vitro or in vivo
Inventors:Nakahata, Tatsutoshi; Matsumoto, Japan
Kawano, Genji; Kamakura, Japan
Sudo, Tetsuo; Kamakura, Japan
Kojima, Katsuaki; Yokohama, Japan
Summary:Described herein is a therapeutic composition comprised of a novel protein which promotes the growth of undifferentiated hemopoietic stem cells. The invention relates to the 18 kDa protein, denominated FDF-3, which has been isolated from cultures of human fibroblasts and has been found to potentiate the growth- and differentiation-promoting activities of certain cytokines toward hematopoietic progenitor cells. Amino acid sequences of the FDF-3 protein are disclosed, wherein one sequence corresponds to that of a C-terminal domain of human fibronectin. Therapeutic applications are included for use of the protein in combination with IL-3, G-CSF, GM-CSF, or stem cell factor (SCF) for the expansion of hematopoietic cell populations in vitro or in treatments which promote recovery from leukopenia or myelosuppresion in vivo.
Abstract:An 18 kDa protein, denominated FDF-3, has been isolated from cultures of human fibroblasts and has been found to potentiate the growth- and differentiation-promoting activities of certain cytokines toward hematopoietic progenitor cells. The amino acid sequence of the FDF-3 protein, shown in SEQ ID NO: 14, corresponds to the sequence of a C-terminal domain of human fibronectin. The protein is useful in combination with IL-3, G-CSF, GM-CSF, or SCF (stem cell factor) in the expansion of hematopoietic cell populations in vitro or in therapeutic methods to promote recovery from leukopenia or myelosuppresion in vivo.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5668104
Application Number:US1994000142449
Date Filed:26/04/1994
Date Published:16/09/1997
Assignee:Toray Industries, Inc., Tokyo, Japan


 
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