Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5674841

Title:Method for inhibiting growth of stem cells
Inventors:Pragnell, Ian B.; Glasgow, United Kingdom
Donaldson, Debra D.; Cambridge, MA, USA
Graham, Gerald J.; Glasgow, United Kingdom
Wong, Gordon G.; Jamaica Plain, MA, USA
Summary:Described herein is a system for inhibiting the growth of hematopoietic stem cells in a mammal via the administration of a stem cell inhibitory protein that is free from other proteins. The invention relates to methods and materials for protecting the cycling or dividing of stem cells from the cytotoxic effects of chemotherapeutic agents and radiation via the administration of such a stem cell inhibitory factor in a suitable composition prior to exposure to these agents. Properties and associated methods of the stem cell inhibitory factor are disclosed herein. Therapeutic applications are directed toward the treatment of patients undergoing chemotherapy and/or radiation therapy.
Abstract:The present invention discloses a method for protecting cycling or dividing stem cells from the cytotoxic effects of chemotherapeutic agents and radiation by administering prior to exposure to these agents, an effective amount of Stem Cell Inhibitory Factor as well as a composition useful therefore.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5674841
Application Number:US1994000230574
Date Filed:21/04/1994
Date Published:07/10/1997
Assignee:Genetics Institute, Inc., Cambridge, MA, USA


 
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