Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5674843

Title:Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor .beta.
Inventors:Carlino, Joseph A.; San Leandro, CA, USA
Summary:This invention describes a system by which the growth factor beta (TGF?) increases hematopoietic progenitor cells in peripheral blood. Described herein are properties of TGF? and methods by which it may be used to increase the numbers of stem cells in a subject's peripheral blood, such that the subject's blood may be drawn and the stem cells removed prior to the administration of myelosuppressive therapy, after which the stem cells are then readministered to the subject. Therapeutic applications are directed toward reducing the toxic effects of chemotherapy and radiation therapy.
Abstract:TGF.beta. is used to increase the numbers of stem cells in a subject's peripheral blood. Then the subject's blood is drawn and the stem cells removed. After myelosuppressive therapy is administered to the subject, the stem cells are administered to the subject. An alternate method provides for TGF.beta. administration to a donor subject whose blood is drawn and from whose blood the stem cells are removed; after a recipient subject receives myelosuppressive therapy, the stem cells are administered to the recipient subject.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5674843
Application Number:US1995000404351
Date Filed:15/03/1995
Date Published:07/10/1997
Assignee:Celtrix Pharmaceuticals, Inc., Santa Clara, CA, USA


 
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