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Stem Cell Related Patent Number US5677136
| Title: | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof | | Inventors: | Simmons, Paul J.; Adelaide, Australia
Hill, Beth L.; Mountain View, CA, USA
Chen, Benjamin P.; Fremont, CA, USA | | Summary: | Described herein is a novel preparation of hematopoietic stem cells that has been enriched by an antibody specific for the HCC-1 epitope. The invention relates to a method for enriching a population of human hematopoietic stem cells via a novel stem cell marker. Disclosed herein are properties of the HCC-1 antibody which is specific for a CD59 epitope that is highly accessible on stem cells but less accessible or absent on mature cells. Therapeutic applications are included for engraftment in cases where cells may be freed of neoplastic cells, and for the use of autologous cells in preventing graft-versus-host disease. | | Abstract: | A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessible on stem cells, and less accessible or absent on mature cells. The enriched population of cells derived from these methods are also provided. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5677136 | | Application Number: | US1994000340047 | | Date Filed: | 14/11/1994 | | Date Published: | 14/10/1997 | | Assignee: | SyStemix, Inc., Palo Alto, CA, USA |
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