Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US5677136

Title:Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
Inventors:Simmons, Paul J.; Adelaide, Australia
Hill, Beth L.; Mountain View, CA, USA
Chen, Benjamin P.; Fremont, CA, USA
Summary:Described herein is a novel preparation of hematopoietic stem cells that has been enriched by an antibody specific for the HCC-1 epitope. The invention relates to a method for enriching a population of human hematopoietic stem cells via a novel stem cell marker. Disclosed herein are properties of the HCC-1 antibody which is specific for a CD59 epitope that is highly accessible on stem cells but less accessible or absent on mature cells. Therapeutic applications are included for engraftment in cases where cells may be freed of neoplastic cells, and for the use of autologous cells in preventing graft-versus-host disease.
Abstract:A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessible on stem cells, and less accessible or absent on mature cells. The enriched population of cells derived from these methods are also provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5677136
Application Number:US1994000340047
Date Filed:14/11/1994
Date Published:14/10/1997
Assignee:SyStemix, Inc., Palo Alto, CA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021