Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5695755

Title:Peripheralization of hematopoietic stem cells
Inventors:Papayannopoulou, Thalia; Seattle, WA, USA
Summary:Described herein is a method for peripheralizing CD 34+ cells, including hematopoietic stem cells, for the treatment of cancer. The invention relates to a process of administering a blocking agent of the VLA-4 antigen on the surface of CD34+ cells, and a stimulating agent of CD34+ cell proliferation in vivo, as part of the therapeutic regimen. Methods and materials are elucidated for all steps of the process, including leukapheresis, enrichment by immunoadsorption, and for the extracorporeal separation of cells after peripheralization.
Abstract:The invention provides methods for peripheralizing CD 34.sup.+ cells, including hematopoietic stem cells. In a first aspect, the method comprises the step of administering a blocking agent of VLA-4 antigen on the surface of CD34.sup.+ cells. In a second aspect, the method comprises administering a blocking agent of VLA-4 antigen on the surface of CD34.sup.+ cells and administering a stimulating agent of CD34.sup.+ cell proliferation in vivo. The method according to the invention is useful in the treatment of cancer or AIDS, and in gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5695755
Application Number:US1995000463128
Date Filed:05/06/1995
Date Published:09/12/1997
Assignee:None


 
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