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Stem Cell Related Patent Number US5700927
| Title: | Tbc1 gene and uses thereof | | Inventors: | Zon, Leonard; Wellesley, MA, USA
Richardson, Paul; Boston, MA, USA | | Summary: | Disclosed herein are properties of a Tbc1 polypeptide, the DNA encoding it, and methods by which the DNA may be utilized to express Tbc1 in leukemic stem cells. Further provided are diagnostic assays for the detection of Tbc1 expression as well as of spermatogenesis disorders and various leukemias. Therapeutic applications in the treatment of leukemia are elucidated. | | Abstract: | Disclosed is a substantially pure DNA encoding a Tbc1 polypeptide; a substantially pure Tbc1 polypeptide; and methods of using such DNA to express Tbc1 in leukemic stem cells and treat certain leukemias. Also disclosed are methods for diagnosing other leukemias and spermatogenesis disorders by assaying for Tbc1 expression. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5700927 | | Application Number: | US1994000363300 | | Date Filed: | 23/12/1994 | | Date Published: | 23/12/1997 | | Assignee: | The Children's Medical Center Corporation, Boston, MA, USA |
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