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Stem Cell Related Patent Number US5731489
| Title: | Transgenic rats containing at least one human gene which participates in blood pressure control | | Inventors: | Ganten, Detlev; 6900 Heidelberg, Germany
Mullins, John; Edinburgh, United Kingdom
Murakami, Kazuo; Ibaraki-Ken, Japan | | Summary: | This invention describes a transgenic rat containing at least one human expression gene for blood pressure regulation. Such transgenic rats contain a genome of which at least one human gene is integrated into the gene product which participates in blood pressure control. More specifically, the invention relates to transgenic rats and their offspring exhibiting increased blood pressure (>90/>140 mm Hg) or high blood pressure (>95/>160 mm Hg), via a transgene which encodes human renin and at least one transgene encoding human angiotensinogen, thereby producing the abnormally high systolic and diastolic pressures. Further disclosed are processes for the production of the transgenic rats and their offspring and their uses in pharmacological studies and screening. | | Abstract: | The present invention relates to transgenic rats in the genome of which at least one human gene is integrated the gene product of which participates in blood pressure control. More specifically, the invention relates to transgenic rats and their offspring exhibiting increased blood pressure (>90/>140 mm Hg) or high blood pressure (>95/>160 mm Hg). Finally, the invention relates to processes for the production of the transgenic rats of the present invention and their offspring and their use for pharmacological tests. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5731489 | | Application Number: | US1995000373495 | | Date Filed: | 17/01/1995 | | Date Published: | 24/03/1998 | | Assignee: | Ganten; Detlev, Heidelberg, Germany |
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