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Stem Cell Related Patent Number US5733543
| Title: | Introduction of HIV-protective genes into cells by particle-mediated gene transfer | | Inventors: | Nabel, Gary J.; Ann Arbor, MI, USA
Woffendin, Clive; Ann Arbor, MI, USA
Yang, Nin-Sun; Verona, WI, USA
Sheehy, Michael J.; Madison, WI, USA | | Summary: | This invention describes particle-mediated gene transfer with HIV-protective genes. Described herein are methods by which the RevM10 gene may be stably introduced into T cells, monocytes, macrophages, dendrites, and hematopoietic stem cells by particle-mediated gene transfer. Further disclosed are properties of the RevM10 gene which is described as encoding a product which inhibits HIV replication. Further disclosed are methods for harvesting a plurality of T cells from a patient infected with HIV, introducing the RevM10 gene into the T cells and reintroducing the cells into the patient for the therapeutic treatment of HIV. | | Abstract: | Foreign genes may be stably introduced into T cells, monocytes, macrophages, dendrites, and hematopoietic stem cells by particle-mediated gene transfer. Introduction of an HIV protective gene into the cells of a patient infected with HIV by particle-mediated gene transfer is effective for the treatment of HIV infection. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5733543 | | Application Number: | US1994000235277 | | Date Filed: | 29/04/1994 | | Date Published: | 31/03/1998 | | Assignee: | None |
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