Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5733543

Title:Introduction of HIV-protective genes into cells by particle-mediated gene transfer
Inventors:Nabel, Gary J.; Ann Arbor, MI, USA
Woffendin, Clive; Ann Arbor, MI, USA
Yang, Nin-Sun; Verona, WI, USA
Sheehy, Michael J.; Madison, WI, USA
Summary:This invention describes particle-mediated gene transfer with HIV-protective genes. Described herein are methods by which the RevM10 gene may be stably introduced into T cells, monocytes, macrophages, dendrites, and hematopoietic stem cells by particle-mediated gene transfer. Further disclosed are properties of the RevM10 gene which is described as encoding a product which inhibits HIV replication. Further disclosed are methods for harvesting a plurality of T cells from a patient infected with HIV, introducing the RevM10 gene into the T cells and reintroducing the cells into the patient for the therapeutic treatment of HIV.
Abstract:Foreign genes may be stably introduced into T cells, monocytes, macrophages, dendrites, and hematopoietic stem cells by particle-mediated gene transfer. Introduction of an HIV protective gene into the cells of a patient infected with HIV by particle-mediated gene transfer is effective for the treatment of HIV infection.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5733543
Application Number:US1994000235277
Date Filed:29/04/1994
Date Published:31/03/1998
Assignee:None


 
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