Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5741646

Title:Cell lines and methods for screening growth regulatory compounds
Inventors:Sherley, James L.; Philadelphia, PA, USA
Riley, Lee B.; Landsdale, PA, USA
Summary:Described herein are novel cell lines containing an exogenous p53 coding sequence operatively linked to an inducible promoter, and methods of use for such cell lines in the screening of growth regulatory compounds. This invention relates to a novel murine cultured cell line which is derived from primary mouse embryo fibroblasts and which exhibits inducer-regulated growth kinetics, such that the cell line has the potential to grow either linearly or exponentially depending on exposure to an appropriate inducing agent. Further claims of the invention include a corresponding cell line that does not respond to the inducing agent, from which a paired cell line system may be used in the development of therapeutic agents that target cells exhibiting deregulated growth kinetics, thereby enabling the identification of potential carcinogenic agents that alter stem cell renewal kinetics.
Abstract:This invention provides a novel murine cultured cell line which is derived from primary mouse embryo fibroblasts and which exhibits inducer-regulated growth kinetics. The cell line has the potential to grow either linearly or exponentially depending on exposure to an appropriate inducing agent. A corresponding cell line that does not respond to the inducing agent is also provided. The paired cell line system provides a valuable research tool for the development of therapeutic agents that target cells exhibiting deregulated growth kinetics, and also enables the identification of potential carcinogenic agents that alter stem cell renewal kinetics.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5741646
Application Number:US1995000578207
Date Filed:29/12/1995
Date Published:21/04/1998
Assignee:Fox Chase Cancer Center, Philadelphia, PA, USA


 
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