Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5747651

Title:Antibodies against tyrosine kinase receptor flk-1
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:This invention introduces isolated antibodies that bind specifically to the extracellular flk-1 portion of a tyrosine kinase protein. Described herein are isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells but not expressed in mature hematopoietic cells. Further disclosed are properties of the receptors and associated ligands, and the nucleic acid molecules encoding both. Also provided are methods of stimulating the proliferation and differentiation of primitive mammalian hematopoietic stem cells by contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase as described herein. Therapeutic applications are included for hematopoietic stem cell proliferation by activation of the receptor in the treatment of a variety of hematopoietic diseases.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5747651
Application Number:US1996000601891
Date Filed:15/02/1996
Date Published:05/05/1998
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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