Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5753505

Title:Neuronal progenitor cells and uses thereof
Inventors:Luskin, Marla B.; Decatur, GA, USA
Summary:Described herein is a composition enriched in non-tumor neuronal progenitor cells with neuron-specific markers. The invention relates to an isolated cellular composition comprising greater than approximately 90% mammalian, non-tumor-derived neuronal progenitor cells which express a neuron-specific marker and which can give rise to progeny which have been shown to differentiate into neuronal cells. Further disclosed are methods of isolating specific cells from the region surrounding the ventricles of a neonatal rat brain and culturing the cells in the absence of mitotic inhibitors. Therapeutic applications are included for the transplantation of neuronal cells developed according to this method in the treatment of Alzheimer's, Parkinson's and Huntington's diseases.
Abstract:The present invention provides an isolated cellular composition comprising greater than about 90% mammalian, non tumor-derived, neuronal progenitor cells which express a neuron-specific marker and which can give rise to progeny which can differentiate into neuronal cells. Also provided are methods of treating neuronal disorders utilizing this cellular composition.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5753505
Application Number:US1995000499093
Date Filed:06/07/1995
Date Published:19/05/1998
Assignee:Emory University, Atlanta, GA, USA


 
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